Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition
نویسندگان
چکیده
منابع مشابه
Photodynamic micelles for amyloid β degradation and aggregation inhibition.
Polymeric micelles loaded with chlorin e6 and Tanshinone I (TAS) were prepared and employed for photodegrading amyloid β (Aβ) aggregates and inhibiting Aβ fibrillation.
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Background and objectives: Alzheimer's disease (AD) as a neurodegenerative disorder is the most common form of dementia in the elderly. According to the amyloid hypothesis, accumulation of amyloid beta (Aβ) plaques, which are mostly constituted of Aβ peptide aggregates, triggers pathological cascades that lead to neuronal cell death. Thus, modulation of Aβ toxicity is the hopef...
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The aggregation of Aβ peptides is a crucial factor leading to Alzheimer's disease (AD). Inhibiting the Aβ peptide aggregation has become one of the most essential strategies to treat AD. In this work, efficient and low-cytotoxicity inhibitors, graphene quantum dots (GQDs) are reported for their application in inhibiting the aggregation of Aβ peptides. Compared to other carbon materials, the low...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease Reports
سال: 2018
ISSN: 2542-4823
DOI: 10.3233/adr-180066